Independent · Not affiliated with NHTSA or any automaker MethodologyData sourcesData refreshed Oct 6, 2026

2010 Mercedes-Benz E350: Problems, Recalls and MPG

What this means

NHTSA lists 4 recall campaigns for the 2010 Mercedes-Benz E350, most recently filed March 2022. Owners have filed 184 complaints with NHTSA, most often about the air bags.

Data summary generated from official records. Methodology Data: NHTSA, DOT, EPA · Refreshed Oct 6, 2026
Compare

Recalls (4)

NHTSA lists 4 recall campaigns for the 2010 Mercedes-Benz E350. Check whether yours was repaired with NHTSA's free VIN lookup ↗

Only NHTSA and your automaker know whether your specific car was repaired. PlainVIN shows every recall campaign listed for a model year, with the official text and how many cars have been fixed so far.

Check on NHTSA ↗
Listed for 2010 Mercedes-Benz E350. Not checked against your VIN.
Recall 22V168000 Filed Mar 18, 2022

Incorrect Software May Cause System Failures

Electronic stability control (esc) · control module · software
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2010 E350, 2014 G550, 2008-2009 C300, 2008 C350, 2009 CLK550, 2007 SL550, SLK280, and 2008 SLK350 vehicles. Various control units may have been updated with incorrect software configuration during a service repair. This can result in various system failures, such as loss of drive power, reduced exterior lighting, or loss of dynamic control functions, including stability and traction control.
Consequence
Various system failures, such as loss of drive power, reduced exterior lighting, or loss of dynamic control functions including stability and traction control, can increase the risk of a crash.
Remedy
Dealers will update the software configuration on the affected control units, free of charge. Owner notification letters were mailed May 3, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040003.
54.6% repairedof 22 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 22V168000
Listed for 2010 Mercedes-Benz E350. Not checked against your VIN.
Recall 18V043000 Filed Jan 10, 2018

Passenger Frontal Air Bag Inflator May Explode

Air bags · frontal · passenger side · inflator module
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2013 C250, C250 Coupe, C350 Coupe 4Matic, C300 4Matic, C350, C350 Coupe, C63 AMG, C63 Coupe, E350 Cabrio, E350 Coupe, E550 Cabrio, E350 Coupe 4Matic, E550 Coupe, GLK350 4Matic, GLK250 Bluetec 4Matic, GLK350, SLS Coupe, SLS AMG GT Coupe, and SLS Roadster vehicles sold, or ever registered, in the states of Alabama, California, Florida, Georgia, Hawaii, Louisiana, Mississippi, South Carolina, Texas, Puerto Rico, American Samoa, Guam, the Northern Mariana Islands (Saipan), and the U.S. Virgin Islands or "Zone A." Additionally, MBUSA is recalling certain 2010 C300, C300 4Matic, C63 AMG, E350 Coupe, E550 Coupe, GLK350, and GLK350 4Matic vehicles ever registered in the states of Arizona, Arkansas, Delaware, District of Columbia, Illinois, Indiana, Kansas, Kentucky, Maryland, Missouri, Nebraska, Nevada, New Jersey, New Mexico, North Carolina, Ohio, Oklahoma, Pennsylvania, Tennessee, Virginia, and West Virginia or "Zone B." MBUSA is also recalling certain 2009 C300, C300 4Matic, C63 AMG, and C350 vehicles ever registered in the states of AK, CO, CT, ID, IA, ME, MA, MI, MN, MO, NH, NY, ND, OR, RI, SD, UT, VT, WA, WI and WY or "Zone C." In the event of a crash necessitating deployment of the passenger frontal air bag, these passenger air bag inflator may explode due to propellant degradation occurring after long-term exposure to absolute humidity and temperature cycling.
Consequence
An inflator explosion may result in sharp metal fragments striking the driver or other occupants resulting in serious injury or death.
Remedy
MBUSA will notify owners, and dealers will replace the passenger frontal air bag module, free of charge. Mercedes issued an interim notification to owners on February 23, 2018. A second notice will be mailed when remedy parts are available. Owners may contact MBUSA customer service at 1-877-496-3691.
93.6% repairedof 132,167 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 18V043000
Listed for 2010 Mercedes-Benz E350. Not checked against your VIN.
Recall 16V363000 Filed May 26, 2016

Passenger Frontal Air Bag Inflator May Rupture

Air bags · frontal · passenger side · inflator module
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain model year 2008-2011 C300 Sedan, C300 4matic Sedan, C350 Sedan, C63 AMG Sedan vehicles, 2010-2011 GLK350, GLK350 4-Matic and E350 Coupe vehicles, 2011 SLS AMG, E350 Convertible, E550 Coupe and E550 Convertible vehicles originally sold, or ever registered, in Alabama, California, Florida, Georgia, Hawaii, Louisiana, Mississippi, South Carolina, Texas, Puerto Rico, American Samoa, Guam, the Northern Mariana Islands (Saipan), and the U.S. Virgin Islands, or "Zone A." Additionally, unless included in "Zone A" above, MBUSA is recalling certain model year 2008 C300 Sedan, C350 Sedan, C63 AMG Sedan and C300 4-Matic Sedan vehicles originally sold, or ever registered, in Arizona, Arkansas, Delaware, District of Columbia, Illinois, Indiana, Kansas, Kentucky, Maryland, Missouri, Nebraska, Nevada, New Jersey, New Mexico, North Carolina, Ohio, Oklahoma, Pennsylvania, Tennessee, Virginia, and West Virginia, or "Zone B." Vehicles not originally sold or ever registered in either Zones A or B are not subject to this safety recall. These vehicles are equipped with certain air bag inflators assembled as part of the passenger frontal air bag modules, and used as original equipment or replacement equipment. In the event of a crash necessitating deployment of the front air bags, these inflators may rupture due to propellant degradation occurring after long-term exposure to absolute humidity and temperature cycling.
Consequence
An inflator rupture may result in metal fragments striking the vehicle occupants resulting in serious injury or death.
Remedy
MBUSA will notify owners, and dealers will replace the passenger frontal air bag modules, free of charge. Owners were sent an interim notification October 2016. A second notice will be mailed when remedy parts are available. Owners may contact MBUSA customer service at 1-877-496-3691.
92.9% repairedof 258,163 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 16V363000
Listed for 2010 Mercedes-Benz E350. Not checked against your VIN.
Recall 16V081000 Filed Feb 11, 2016

Driver's Frontal Air Bag Inflator May Rupture

Air bags · frontal · driver side · inflator module
Official NHTSA text
Summary
Mercedes-Benz USA, LLC. (MBUSA) is recalling certain model year 2009-2010 ML320 BlueTec 4Matic, GL320 BlueTec 4Matic and R320 CDI 4Matic, 2011 E350 Cabriolet and E550 Cabriolet, 2009-2011 ML350, ML350 4Matic, ML550 4Matic, ML63 AMG, and C63 AMG, 2010-2011 ML450 4Matic Hybrid, E350 Coupe, E350 4Matic, E550 Coupe, E550 4Matic, and E63 AMG, 2011-2012 GL350 BlueTec 4Matic and R350 BlueTec 4Matic, 2009-2012 GL450 4Matic, GL550 4Matic and R350 4Matic, 2007-2008 SLK280, SLK350, and SLK55 AMG, 2011-2014 SLS AMG Coupe, 2012 SLS AMG Cabriolet, 2013-2014 SLS AMG GT and SLS AMG GT Cabriolet, 2005 C230 Kompressor and C320, 2006-2007 C230, 2006-2011 C350, 2008-2011 C300 and C300 4Matic, 2010-2012 GLK350 and GLK350 4Matic and 2007-2008 Chrysler Crossfire vehicles. Upon deployment of the driver's frontal air bag, excessive internal pressure may cause the inflator to rupture.
Consequence
In the event of a crash necessitating deployment of the driver's frontal air bag, the inflator could rupture with metal fragments striking the driver or other occupants resulting in serious injury or death.
Remedy
MBUSA will their notify owners, and Fiat Chrysler will notify the affected Chrysler owners. Dealers for the respective brands will replace the driver's frontal air bag module, free of charge. This recall began November 2016. Mercedes-Benz owners may contact MBUSA customer service at 1-800-367-6372 and Chrysler owners may contact Fiat Chrysler customer service at 1-800-853-1403.
92.5% repairedof 711,159 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 16V081000

PlainVIN shows public government records for education. It isn't a vehicle inspection or legal advice. Check your own VIN with NHTSA or your dealer.

Owner complaints (184)

184 complaints filed with NHTSA (owner reports, not verified findings). The air bags is mentioned most often.

9involved a crash
0involved a fire
6injuries reported
0deaths reported

As reported by owners in their complaints. These are reports, not NHTSA findings.

Most-reported components

Complaints filed with NHTSA for the 2010 Mercedes-Benz E350, by component (top 10). One complaint can list several components, so these add up to more than 184.Source: NHTSA ODI owner complaints · Retrieved Oct 6, 2026 · Report a data error

How 2010 compares with other E350 years

Best and worst E350 years →
2006200720082009201020112012201320142015
This year (2010)Other yearsStill collecting reports

Counts are owner reports, not failure rates. Higher sales years tend to draw more reports. Owners are still filing reports for recent model years, so these counts will grow. Source: NHTSA ODI, retrieved Oct 6, 2026.

Fuel economy: up to 21 mpg combined

21
mpg combined
18
city
26
highway
EPA annual fuel cost
$3,900
CO₂ tailpipe
423 g/mi
EPA class
Midsize Cars

What it costs you to run

$3,110per year
$259per month
714gallons a year

Miles ÷ 21 mpg × $4.354 (EIA US average regular, week of Oct 5, 2026, all taxes included). Source: EPA · EIA.

EPA label estimates from lab tests; your mileage will vary.

Specs by configuration

2010 Mercedes-Benz E350 configurations with EPA data
Engine · transmissionDriveCity / Hwy / CombEPA $/yrCO₂ g/mi
3.5 L 6-cyl · 7-speed automaticRear-Wheel Drive18 / 26 / 21$3,900423
3.5 L 6-cyl · 7-speed automaticRear-Wheel Drive17 / 26 / 20$4,100444

Source: EPA fuel economy data, retrieved Oct 6, 2026. Configurations are listed when EPA and NHTSA records match.

Used blue SUV on a sunny dealer lot with its hood open and a clipboard on the fender

Looking at a 2010 E350 for sale?

Print a one-page buyer's checklist: each recall campaign with a box to tick when the seller shows proof of repair, the top complaint areas to inspect, crash stars, MPG, and a link back to this page.

All E350 years

Where to next

2010 Mercedes-Benz E350 FAQ

How many recalls does the 2010 Mercedes-Benz E350 have?

NHTSA lists 4 recall campaigns: 22V168000 (engine), 18V043000 (air bag), 16V363000 (air bag), 16V081000 (air bag). Use NHTSA's VIN lookup to see whether a specific car was repaired.

What are the most common 2010 Mercedes-Benz E350 problems?

Owners filed 184 complaints with NHTSA. Air bags (68), Unknown or other (19), Fuel/propulsion system (18) are mentioned most. These are owner reports, not verified findings.

What mpg does the 2010 Mercedes-Benz E350 get?

EPA rates the 3.5 L 6-cyl · 7-speed automatic version at 18 city, 26 highway and 21 combined mpg. Other configurations are listed in the fuel economy section.

How does the 2010 E350 compare with other years?

Among the 2006–2015 Mercedes-Benz E350 model years at least five years old, the 2015 drew the fewest complaints (31) and the 2006 the most (399). The 2010 drew 184. Counts are owner reports, not failure rates.

How this page was madeSources, processing, limits, review and changes

Processing

  • Complaints are counted per component. One complaint can list several, so component totals add up to more than the total.
  • Fuel cost = miles per year ÷ EPA combined mpg × EIA weekly price for your region.

Limitations

  • Complaint counts are owner reports, not verified findings or failure rates. There is no sales denominator.
  • Recall campaigns are listed for the model year. Only NHTSA and the automaker know whether a specific car was repaired.
  • Recent model years are still collecting reports.

Review

Data compiled automatically from the official files listed here.

Changelog

  • 2026-10-06 Data refreshed from the official files.
Was this report useful?Report a data error
My Garage
Save this car and we'll flag new recall campaigns next time you visit.