Independent · Not affiliated with NHTSA or any automaker MethodologyData sourcesData refreshed Oct 6, 2026

2021 Mercedes-Benz E 450: Problems, Recalls and MPG

What this means

NHTSA lists 14 recall campaigns for the 2021 Mercedes-Benz E 450, most recently filed February 2024. Owners have filed 7 complaints with NHTSA, most often about the electrical system.

Data summary generated from official records. Methodology Data: NHTSA, DOT, EPA · Refreshed Oct 6, 2026
Caution Fewer than 50 complaints filed. With this few reports, patterns may not be meaningful.
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Recalls (14)

NHTSA lists 14 recall campaigns for the 2021 Mercedes-Benz E 450. Check whether yours was repaired with NHTSA's free VIN lookup ↗

Only NHTSA and your automaker know whether your specific car was repaired. PlainVIN shows every recall campaign listed for a model year, with the official text and how many cars have been fixed so far.

Check on NHTSA ↗
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 24V100000 Filed Feb 9, 2024

48-Volt Ground Cable Not Tightened Properly

Electrical system · wiring
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 CLS450, E450, E450 All-Terrain, AMG E53, AMG GT43, AMG GT53, and 2021 AMG CLS53 vehicles. The 48-volt ground cable connection located in the engine compartment may not be tightened properly and may result in the ground cable overheating.
Consequence
An overheated ground cable increases the risk of a fire.
Remedy
Dealers will inspect the 48-volt ground cable connection and repair it as necessary, free of charge. Owner notification letters were mailed March 22, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2024MMNNNN.
95.3% repairedof 12,191 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 24V100000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 22V733000 Filed Sep 30, 2022

Disabled Safety Features from Unsecure 12V Battery

Electrical system · 12v/24v/48v battery
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2022 CLS450 Coupe and AMG E53, 2019-2021 AMG CLS53 Coupe, and 2021-2022 E450 vehicles. The 12-Volt battery in the trunk may not be properly secured, which, in the event of a crash, can cause electrical connection failure, disabling various safety features including, emergency call (eCall) system, electric seat adjustment, hazard warning lights, and automatic door locks.
Consequence
The inability to operate safety features (eCall system, hazard lights, electric seats, or automatic door locks) can increase the risk of injury during a crash.
Remedy
Dealers will secure the 12V battery, free of charge. Owner notification letters were mailed January 20, 2023. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022100009.
92.8% repairedof 19,968 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 22V733000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 22V365000 Filed May 20, 2022

Disabled Emergency Call System

Communication · auto crash notification
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2017-2022 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, AMG GT-Class, C-Class, E-Class, S-Class, SL-Class, GLC-Class, CLS-Class, GLB-Class, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. An error in the communication module's SIM card software can cause a mobile network connection failure, disabling the emergency call (eCall) system.
Consequence
A disabled eCall system would prevent a vehicle occupant from contacting the emergency services call center in an emergency, potentially delaying emergency responders and increasing the risk of injury.
Remedy
The communication module software will be updated through an Over-the-Air (OTA) update or by a dealer, free of charge. Owner notification letters were mailed July 8, 2022. Owner notification letters will be mailed in phases, on July 8, 2022, May 17, 2024, July 29, 2024, and September 27, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's numbers are for this recall is 2022060005 and 2023110006.
90.6% repairedof 242,722 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 22V365000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 22V232000 Filed Apr 8, 2022

Inoperable Rearview Camera Display/FMVSS 111

Back over prevention · display function
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2018-2021 CLA-Class, GLE/GLS-Class, A-Class, C-Class, E-Class, E-Class Coupe/Convertible, GLA/GLB-Class, GLC-Class, and CLS-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The rearview camera may not display the rearview image due to a software error. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 111, "Rear Visibility."
Consequence
An inoperable rearview camera display reduces the driver's rear view, increasing the risk of a crash.
Remedy
Dealers will update the rearview camera software, free of charge. Owner notification letters were mailed July 15, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022060007.
92.4% repairedof 126,443 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 22V232000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 22V189000 Filed Mar 25, 2022

Steering Wheel Hands-Off Detection Software Error

Steering · steering wheel/handle bar
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the driver's hands are away from the steering wheel when using the Active Distance Assist DISTRONIC system.
Consequence
Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.
Remedy
Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.
97.9% repairedof 8,396 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 22V189000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 21V527000 Filed Jul 12, 2021

Side Impact Crash Sensor Connectors May Loosen

Air bags · sensor · side impact
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 CLS450, AMG E53, AMG CLS53, E350, E450, AMG GT43, AMG GT53, 2020 S450, S560, G550, AMG GLC63, 2020-2021 GLC300, and AMG G63 vehicles. The side crash sensor connectors may come loose, which could delay the activation of air bags and seatbelts during a side impact crash.
Consequence
Air bags and seatbelts that don't function as intended can increase the risk of injury during a crash.
Remedy
Dealers will inspect and replace as necessary, the side impact crash sensors, free of charge. Owner notification letters were mailed on September 3, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021070032/33.
94.7% repairedof 542 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 21V527000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 21V483000 Filed Jun 25, 2021

Seat Belt Locking Retractor Malfunction/FMVSS 208

Seat belts · rear/other · retractor
Official NHTSA text
Summary
Mercedes-Benz, LLC (MBUSA) is recalling certain 2021 G550, AMG G63, E350, E450, AMG CLS53, AMG E53, AMG GT43, AMG GT53, AMG GT63, 2021-2022 CLS450, and AMG E63 vehicles. The rear seat belt automatic locking retractors may deactivate early, which can prevent the child restraint system from securing properly. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 208, "Occupant Crash Protection."
Consequence
An unsecured child restraint system can increase the risk of injury during a crash.
Remedy
Dealers will inspect, and replace as necessary, the rear seat belt assemblies, free of charge. Owners notified of the voluntary recall campaign by an interim letter on August 13, 2021. A final letter was mailed on September 24, 2021. Owners may contact MBUSA customer service at 1-800-367-6372.
96.6% repairedof 4,917 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 21V483000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 21V406000 Filed May 28, 2021

Improperly Mounted Rear Headrests

Seats · mid/rear assembly · head restraint
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 C300 Cabriolet, C43 AMG Cabriolet, C63 AMG Cabriolet, C63 AMG S Cabriolet, E450 Cabriolet, and E53 AMG Cabriolet vehicles. The rear headrests may be incorrectly mounted to the seatbacks.
Consequence
Incorrectly mounted headrests could move or detach from the seat during a crash, increasing the risk of injury.
Remedy
Dealers will inspect the rear seatback guide bushings and replace them if necessary, free of charge. Owner notification letters were mailed July 16, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021060010.
99.1% repairedof 218 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 21V406000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 21V354000 Filed May 14, 2021

Rearview Camera Image May Not Display/FMVSS 111

Back over prevention · sensing system · camera
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLA-Class, GLE/GLS-Class, A-Class, E-Class, E-Class Coupe and Convertible, GLA/GLB-Class, GLC-Class, CLS-Class, and AMG GT-Class 4-door Coupe vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The MBUX multimedia system software may cause the display to remain black, or reboot after startup. This could result in the rearview camera image not displaying properly. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard (FMVSS) number 111, "Rear Visibility."
Consequence
A backup camera that displays a blank image reduces the driver's rear view, increasing the risk of a crash or injury.
Remedy
The multimedia system software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. Owner notification letters were mailed beginning June 28, 2021. Owners may contact MBUSA customer service at 1-800-367-6373. MBUSA's number for this recall is 2021050012.
96.5% repairedof 343,191 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 21V354000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 21V228000 Filed Apr 1, 2021

Rearview Camera and Parking Sensors Malfunction

Back over prevention · sensing system · camera
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, and AMG E63 vehicles. The parking control unit may fail to display the rearview camera image and cause the parking sensors to misidentify or fail to detect objects.
Consequence
An inoperative rearview camera display and/or parking sensors can reduce the driver's view and awareness of what is behind the vehicle, increasing the risk of a crash.
Remedy
All affected vehicles are still within MBUSA's control. MBUSA will replace the parking control unit, free of charge. The recall began April 8, 2021. Owner may contact MBUSA customer service at 1-800-367-6372.
100% repairedof 6 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 21V228000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 21V230000 Filed Apr 1, 2021

Faulty Front Seat Position Switch

Air bags · sensor · occupant classification
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 C-Class, E-Class, E-Class Coupe and Convertible, GLC, CLS, AMG GT 4-door Coupe and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. A faulty electrical contact within the seat position switch may prevent the driver and passenger air bags and seat belt force limiters from properly activating during a crash.
Consequence
Air bags and seat belts that do not perform properly in a crash can increase the risk of injury.
Remedy
MBUSA will notify owners, and dealers will replace the seat position switches, free of charge. Owner letters were mailed May 21, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040016.
97.8% repairedof 8,634 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 21V230000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 21V216000 Filed Mar 26, 2021

Seat Limiter may Allow Seat too Close to Air Bag

Seats
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, E63S AMG, 2020 E63S AMG Wagon, and 2020-2021 E53 AMG vehicles. The passenger seat limiter may allow the seat to be positioned too close to the air bag.
Consequence
A seat too close to the air bag increases the risk of injury in the event of a crash necessitating the deployment of the frontal passenger air bag.
Remedy
MBUSA will notify owners, and dealers will recalibrate the passenger seat limiter, free of charge. The recall began April 29, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040002.
98.2% repairedof 109 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 21V216000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 21V058000 Filed Feb 5, 2021

Inaccurate Vehicle Location for Emergency Services

Communication · auto crash notification
Official NHTSA text
Summary
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2016 - 2021 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, GT-Class, C-Class, E-Class, S-Class, CLS-Class, SL-Class, B-Class, GLB-Class, GLC-Class, and G-Class vehicles. Please refer to the Part 573 report for specific vehicle model details. The software design of the communication module may fail to communicate the correct vehicle location for the emergency call system (eCall) in the event of a crash.
Consequence
Failure of the eCall system may result in emergency responders being dispatched to the wrong location, increasing the risk of injury following a crash.
Remedy
MBUSA will notify owners, and the communication module software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. The recall began March 12, 2021. Owners may contact MBUSA customer service at 1-877-762-8267. MBUSA's number for this recall is 2021020025.
95.3% repairedof 1,292,258 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 21V058000
Listed for 2021 Mercedes-Benz E 450. Not checked against your VIN.
Recall 20V673000 Filed Oct 30, 2020

Front Passenger Seat Missing Adjustment Limit Stop

Seats
Official NHTSA text
Summary
Mercedes-Benz USA, LLC. (MBUSA) is recalling certain 2021 E350 and E450, 2019-2021 AMG E53 and 2020-2021 AMG E63 vehicles. The front passenger seat may be missing the mechanical seat adjustment range limit stop, allowing the seat to move outside of the acceptable range in relation to the air bag.
Consequence
If the front passenger seat is adjusted beyond the acceptable range in relation to the air bag, there could be an increased risk of injury in the event of a crash with air bag deployment.
Remedy
MBUSA will notify owners, and dealers will inspect for the mechanical seat adjustment range limitation for the front passenger seat and install it if necessary, free of charge. The recall began December 18, 2020. Owners may contact MBUSA customer service at 1-800-368-6372. MBUSA's number for this recall is 2020110013.
98% repairedof 1,337 vehicles
Manufacturer report to NHTSA · Source: US DOT recall completion data, retrieved Oct 6, 2026
Check your VIN on NHTSA or ask a dealer to check campaign 20V673000

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Owner complaints (7)

7 complaints filed with NHTSA (owner reports, not verified findings). The electrical system is mentioned most often.

0involved a crash
0involved a fire
0injuries reported
0deaths reported

As reported by owners in their complaints. These are reports, not NHTSA findings.

Most-reported components

Complaints filed with NHTSA for the 2021 Mercedes-Benz E 450, by component (top 4). One complaint can list several components, so these add up to more than 7.Source: NHTSA ODI owner complaints · Retrieved Oct 6, 2026 · Report a data error

How 2021 compares with other E 450 years

Best and worst E 450 years →
17 9 7 11 17 2
201920202021202220232024
This year (2021)Other yearsStill collecting reports

Counts are owner reports, not failure rates. Higher sales years tend to draw more reports. Owners are still filing reports for recent model years, so these counts will grow. Source: NHTSA ODI, retrieved Oct 6, 2026.

Fuel economy: up to 26 mpg combined

26
mpg combined
23
city
31
highway
EPA annual fuel cost
$3,150
CO₂ tailpipe
341 g/mi
EPA class
Subcompact Cars

What it costs you to run

$2,512per year
$209per month
577gallons a year

Miles ÷ 26 mpg × $4.354 (EIA US average regular, week of Oct 5, 2026, all taxes included). Source: EPA · EIA.

EPA label estimates from lab tests; your mileage will vary.

Specs by configuration

2021 Mercedes-Benz E 450 configurations with EPA data
Engine · transmissionDriveCity / Hwy / CombEPA $/yrCO₂ g/mi
3 L 6-cyl · 9-speed automaticRear-Wheel Drive23 / 31 / 26$3,150341
3 L 6-cyl · 9-speed automaticRear-Wheel Drive23 / 30 / 25$3,300349

Source: EPA fuel economy data, retrieved Oct 6, 2026. Configurations are listed when EPA and NHTSA records match.

Used blue SUV on a sunny dealer lot with its hood open and a clipboard on the fender

Looking at a 2021 E 450 for sale?

Print a one-page buyer's checklist: each recall campaign with a box to tick when the seller shows proof of repair, the top complaint areas to inspect, crash stars, MPG, and a link back to this page.

All E 450 years

Where to next

2021 Mercedes-Benz E 450 FAQ

How many recalls does the 2021 Mercedes-Benz E 450 have?

NHTSA lists 14 recall campaigns: 24V100000 (electrical), 22V733000 (electrical), 22V365000 (electrical), 22V232000 (rear camera), 22V189000 (steering), 21V527000 (air bag), 21V483000 (seat belt), 21V406000 (seat), 21V354000 (electrical), 21V228000 (rear camera), 21V230000 (air bag), 21V216000 (seat), 21V058000 (electrical), 20V673000 (seat). Use NHTSA's VIN lookup to see whether a specific car was repaired.

What are the most common 2021 Mercedes-Benz E 450 problems?

Owners filed 7 complaints with NHTSA. Electrical system (3), Engine (2), Unknown or other (2) are mentioned most. These are owner reports, not verified findings.

What mpg does the 2021 Mercedes-Benz E 450 get?

EPA rates the 3 L 6-cyl · 9-speed automatic version at 23 city, 31 highway and 26 combined mpg. Other configurations are listed in the fuel economy section.

How does the 2021 E 450 compare with other years?

Among the 2019–2021 Mercedes-Benz E 450 model years at least five years old, the 2021 drew the fewest complaints (7) and the 2019 the most (17). The 2021 drew 7. Counts are owner reports, not failure rates.

How this page was madeSources, processing, limits, review and changes

Processing

  • Complaints are counted per component. One complaint can list several, so component totals add up to more than the total.
  • Fuel cost = miles per year ÷ EPA combined mpg × EIA weekly price for your region.

Limitations

  • Complaint counts are owner reports, not verified findings or failure rates. There is no sales denominator.
  • Recall campaigns are listed for the model year. Only NHTSA and the automaker know whether a specific car was repaired.
  • Recent model years are still collecting reports.

Review

Data compiled automatically from the official files listed here.

Changelog

  • 2026-10-06 Data refreshed from the official files.
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